Ketamine’s mechanism explained

By blocking the NMDA receptor, ketamine can induce a dissociative state where the individual experiences a sense of detachment from reality, altered perception of space and time, and a feeling of being outside of their body. This dissociative state can also cause side effects such as hallucinations, confusion, and delirium. This receptor is involved in the transmission of pain signals, the formation of memories, and the regulation of mood and cognition.

In addition to its effects on the NMDA receptor, ketamine also affects other neurotransmitter systems in the brain, including the glutamate, dopamine, and serotonin systems. These effects may contribute to its antidepressant and analgesic (pain-relieving) effects.

Recent research has also suggested that ketamine may have neuroprotective effects and may promote the growth of new neurons in the brain, which could have implications for the treatment of certain neurological and psychiatric disorders. However, more research is needed to fully understand these effects and their potential therapeutic applications.